99% Purity Chloramphenicol 56-75-7

Product Description

    Chloramphenicol is a broad spectrum antibiotic which inhibits translation on the 50S
ribosomal subunit at the peptidyltransferase step. It is usually bacteristatic and effective
against a wide range of gram-positive and gram-negative organisms. Chloramphenicol
exhibits anti-rickettsial activity and is also active against chlamydias of the
psittacosis-lymphogranuloma group. Obtained from cultures of the soil bacterium Streptomyces venuzuelae isolated from the moon snail, Lunatia heros and produced synthetically. Useful for the selection of the bacterial CAT gene.

Application
    Chloramphenicol is unusual nitroaromatic metabolite produced by Streptomyces venezuelae, first published in 1947. Chloramphenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Although restricted to ocular use, antibiotic resistance to other classes has refocused attention on this class. Chloramphenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. Chloramphenicol has been extensively studied with over 35,000 literature citations.