99% Purity Calcitriol 32222-06-3

What is Calcitriol?

Calcitriol is a 1,25-dihydroxy metabolite with the strongest anti-rickets activity after vitamin D3 is metabolized by liver and kidney hydroxylase. It can promote the absorption of calcium in the intestine; it can stimulate the activity of the original osteoclasts or accelerate the formation of new osteoclasts, thereby promoting the absorption of bone, so that the calcium and phosphorus in the blood can be transferred into the blood circulation; it can promote the calcium and phosphorus in the proximal convoluted tubules of the kidney The absorption of phosphorus increases blood calcium and phosphorus concentrations. After oral administration, it is quickly absorbed from the small intestine, without metabolic activation, and partly degraded by the kidneys.

Function of Calcitriol

1)Calcium regulator, anti-psoriatic;

2)Vitamin medicines; it can be used for treating the renal bone malnutrition of patients with chronic renal failure;

3)The biologically active form of vitamin D3. Calcium regulator; vitamin (antirachitic); antihyperparathyroid; antineoplastic; antipsoriati.

Application of Calcitriol
1. For rickets, such as vitamin D-dependent rickets, hypophosphatemic vitamin D-resistant rickets, etc.
2. Osteoporosis (mainly used for menopausal women and senile osteoporosis).
3. For idiopathic, pseudo- and postoperative hypoparathyroidism. High-dose intravenous administration can be used for pseudohypoparathyroidism caused by renal failure.
4. Used for renal osteodystrophy, such as renal osteodystrophy caused by patients with chronic renal failure (especially those undergoing hemodialysis or peritoneal dialysis).
5. For osteomalacia.